From The Polyploidy Portal

Maintenance of heterochromatin by RNA interference of tandem repeats

Martienssen RA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Abstract:
Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats. [1]

  1. Martienssen RA (2003) Maintenance of heterochromatin by RNA interference of tandem repeats. Nat Genet 35: 213-4 PubMed
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